INCREASED OXPHOS ACTIVITY PRECEDES RISE IN GLYCOLYTIC RATE IN H-RASV12/E1A TRANSFORMED FIBROBLASTS THAT DEVELOP A WARBURG PHENOTYPE

Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

Abstract Background The Warburg phenotype in cancer cells has been long recognized, but there is still limited insight in the consecutive metabolic alterations that characterize its establishment.We obtained better understanding of the coupling between metabolism and malignant Clippers transformation by studying mouse embryonic fibroblast-derived c

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Effects of Guideline-Based Correction of Platelet Inhibition on Outcomes in Moderate to Severe Isolated Blunt Traumatic Brain Injury

Platelet dysfunction has been demonstrated after traumatic brain injury (TBI) regardless of the use of platelet inhibitors.The purpose of this study was to determine the efficacy of a platelet-mapping thromboelastography (PM-TEG) in predicting TBI patients who would benefit from platelet transfusion.We hypothesized that adenosine diphosphate (ADP)

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